Improving diffuse optical tomography with structural a priori from fluorescence diffuse optical tomography

Wenjuan Ma; Feng Gao; Linjing Duan; Qingzhen Zhu; Xin Wang; Wei Zhang; Linhui Wu; Xi Yi; Huijuan Zhao

doi:10.1117/12.907020

2 February 2012 Improving diffuse optical tomography with structural a priori from fluorescence diffuse optical tomography

Wenjuan Ma, Feng Gao, Linjing Duan, Qingzhen Zhu, Xin Wang, Wei Zhang, Linhui Wu, Xi Yi, Huijuan Zhao

Author Affiliations +

Proceedings Volume 8230, Biomedical Applications of Light Scattering VI; 823017 (2012) https://doi.org/10.1117/12.907020
Event: SPIE BiOS, 2012, San Francisco, California, United States

Abstract

We obtain absorption and scattering reconstructed images by incorporating a priori information of target location obtained from fluorescence diffuse optical tomography (FDOT) into the diffuse optical tomography (DOT). The main disadvantage of DOT lies in the low spatial resolution resulting from highly scattering nature of tissue in the near-infrared (NIR), but one can use it to monitor hemoglobin concentration and oxygen saturation simultaneously, as well as several other cheomphores such as water, lipids, and cytochrome-c-oxidase. Up to date, extensive effort has been made to integrate DOT with other imaging modalities such as MRI, CT, to obtain accurate optical property maps of the tissue. However, the experimental apparatus is intricate. In this study, DOT image reconstruction algorithm that incorporates a prior structural information provided by FDOT is investigated in an attempt to optimize recovery of a simulated optical property distribution. By use of a specifically designed multi-channel time-correlated single photon counting system, the proposed scheme in a transmission mode is experimentally validated to achieve simultaneous reconstruction of the fluorescent yield, lifetime, absorption and scattering coefficient. The experimental results demonstrate that the quantitative recovery of the tumor optical properties has doubled and the spatial resolution improves as well by applying the new improved method.

Citation Download Citation

Wenjuan Ma, Feng Gao, Linjing Duan, Qingzhen Zhu, Xin Wang, Wei Zhang, Linhui Wu, Xi Yi, and Huijuan Zhao "Improving diffuse optical tomography with structural a priori from fluorescence diffuse optical tomography", Proc. SPIE 8230, Biomedical Applications of Light Scattering VI, 823017 (2 February 2012); https://doi.org/10.1117/12.907020

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