Photosensitization of InP/ZnS quantum dots for anti-cancer and anti-microbial applications

Jay Nadeau; Hicham Chibli; Lina Carlini

doi:10.1117/12.913648

2 February 2012 Photosensitization of InP/ZnS quantum dots for anti-cancer and anti-microbial applications

Jay Nadeau, Hicham Chibli, Lina Carlini

Author Affiliations +

Proceedings Volume 8232, Colloidal Nanocrystals for Biomedical Applications VII; 82320I (2012) https://doi.org/10.1117/12.913648
Event: SPIE BiOS, 2012, San Francisco, California, United States

Abstract

Cadmium-free quantum dots (QDs), such as those made from InP, show similar optical properties to those containing toxic heavy metals and thus provide a promising alternative for imaging and therapeutics. The band gap of InP is similar to that of CdTe, so photosensitization of InP QDs with porphyrins or other dyes should lead to generation of reactive oxygen species, useful for targeted destruction of malignant cells or pathogenic bacteria. Here we show the results of measurements of singlet oxygen and superoxide generation from InP QDs with single and double ZnS shells compared with CdTe and CdSe/ZnS. Reactive oxygen species are measured using colorimetric or fluorescent reporter assays and spin-trap electron paramagnetic resonance (EPR) spectroscopy. We find that the size of the InP QDs and the thickness of the ZnS shell both strongly influence ROS generation. These results suggest future approaches to the design of therapeutic nanoparticles.

Citation Download Citation

Jay Nadeau, Hicham Chibli, and Lina Carlini "Photosensitization of InP/ZnS quantum dots for anti-cancer and anti-microbial applications", Proc. SPIE 8232, Colloidal Nanocrystals for Biomedical Applications VII, 82320I (2 February 2012); https://doi.org/10.1117/12.913648

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