Visualization of mappings between the gene ontology and cluster trees

Ilir Jusufi; Andreas Kerren; Vladyslav Aleksakhin; Falk Schreiber

doi:10.1117/12.906700

24 January 2012 Visualization of mappings between the gene ontology and cluster trees

Ilir Jusufi, Andreas Kerren, Vladyslav Aleksakhin, Falk Schreiber

Proceedings Volume 8294, Visualization and Data Analysis 2012; 82940N (2012) https://doi.org/10.1117/12.906700
Event: IS&T/SPIE Electronic Imaging, 2012, Burlingame, California, United States

Abstract

Ontologies and hierarchical clustering are both important tools in biology and medicine to study high-throughput data such as transcriptomics and metabolomics data. Enrichment of ontology terms in the data is used to identify statistically overrepresented ontology terms, giving insight into relevant biological processes or functional modules. Hierarchical clustering is a standard method to analyze and visualize data to find relatively homogeneous clusters of experimental data points. Both methods support the analysis of the same data set, but are usually considered independently. However, often a combined view is desired: visualizing a large data set in the context of an ontology under consideration of a clustering of the data. This paper proposes a new visualization method for this task.

Citation Download Citation

Ilir Jusufi, Andreas Kerren, Vladyslav Aleksakhin, and Falk Schreiber "Visualization of mappings between the gene ontology and cluster trees", Proc. SPIE 8294, Visualization and Data Analysis 2012, 82940N (24 January 2012); https://doi.org/10.1117/12.906700

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