A highly sensitive biological detection substrate based on TiO2 nanowires supporting gold nanoparticles

Yuan Zeng; Hai-jun Tan; Xiu-Lan Cheng; Rui Chen; Ying Wang

doi:10.1117/12.904317

29 November 2011 A highly sensitive biological detection substrate based on TiO₂ nanowires supporting gold nanoparticles

Yuan Zeng, Hai-jun Tan, Xiu-Lan Cheng, Rui Chen, Ying Wang

Author Affiliations +

Proceedings Volume 8311, Optical Sensors and Biophotonics III; 83110H (2011) https://doi.org/10.1117/12.904317
Event: SPIE/OSA/IEEE Asia Communications and Photonics, 2011, Shanghai, China

Abstract

Surface enhanced Raman scattering (SERS) has attracted widespread concern in the field of bioassay because it can enhance normally weak Raman signal by several orders of magnitude and facilitate the highly sensitive detection of molecules. Conventional SERS substrates are prepared by placing metal nanoparticles on a planar surface. Here we show a unique SERS substrate stacked by disordered TiO₂ nanowires (TiO₂-NWs) supportig gold nanocrystals. The structure can be easily fabricated by chemical synthesis at low cost. The COMSOL model simulation shows the designed SERS substrate is capable of output high Local Field Enhancement (LFE) in the Near Infrared region (NIR) that is the optimal wavelength in bio-detection because of both the unique coupling enhancement effect amony nearby Au nanocrystals on TiO₂-NWs and the Suface Plasmon Resonance (SPR) effect of TiO₂ -NWs. The as-prepared transparent and freestanding SERS substrate is capable of detecting extremely low concentration R6G molecular, showing much higher Raman signal because of the extremely large surface area and the uniqueTiO₂-NWs self-assemblied by Au nanocrystals. These results provide a new approach to ultrasensitive bioassay device.

Citation Download Citation

Yuan Zeng, Hai-jun Tan, Xiu-Lan Cheng, Rui Chen, and Ying Wang "A highly sensitive biological detection substrate based on TiO₂ nanowires supporting gold nanoparticles", Proc. SPIE 8311, Optical Sensors and Biophotonics III, 83110H (29 November 2011); https://doi.org/10.1117/12.904317

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