Negative BOLD response and serotonin concentration within rostral subgenual portion of the anterior cingulate cortex for long-allele carriers during perceptual processing of emotional tasks

Shamil M. Hadi; Mohamad R. Siadat; Abbas Babajani-Feremi

doi:10.1117/12.905188

12 April 2012 Negative BOLD response and serotonin concentration within rostral subgenual portion of the anterior cingulate cortex for long-allele carriers during perceptual processing of emotional tasks

Shamil M. Hadi, Mohamad R. Siadat, Abbas Babajani-Feremi

Author Affiliations +

Proceedings Volume 8317, Medical Imaging 2012: Biomedical Applications in Molecular, Structural, and Functional Imaging; 83170A (2012) https://doi.org/10.1117/12.905188
Event: SPIE Medical Imaging, 2012, San Diego, California, United States

Abstract

A negative blood oxygen level - dependent (BOLD) has been associated with a high concentration of GABA using Magnetic Resonance Spectroscopy and fMRI. Subjects with long-allele carriers have seen with high concentration of serotonin in Rostral Subgenual portion of the anterior cingulate cortex (rACC). In this paper, we investigate the effect of serotonin concentration on hemodynamic responses. Our results show a negative BOLD signal in rACC in the subjects with long-allele carriers. In contrast, the subjects with short-allele carriers showed positive BOLD signals in rACC. These results suggest that the serotonin transporter gene impacts the neuronal activity and eventually the BOLD signal similar to GABA.

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Shamil M. Hadi, Mohamad R. Siadat, and Abbas Babajani-Feremi "Negative BOLD response and serotonin concentration within rostral subgenual portion of the anterior cingulate cortex for long-allele carriers during perceptual processing of emotional tasks", Proc. SPIE 8317, Medical Imaging 2012: Biomedical Applications in Molecular, Structural, and Functional Imaging, 83170A (12 April 2012); https://doi.org/10.1117/12.905188

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KEYWORDS

Amygdala

Functional magnetic resonance imaging

Sensors

Signal processing

Hemodynamics

Neurotransmitters

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