Self-demodulation effect on subharmonic response of ultrasound contrast agent

V. Daeichin; T. Faez; A. Needles; G. Renaud; J. G. Bosch; A. F. W. van der Steen; N. de Jong

doi:10.1117/12.912461

24 February 2012 Self-demodulation effect on subharmonic response of ultrasound contrast agent

V. Daeichin, T. Faez, A. Needles, G. Renaud, J. G. Bosch, A. F. W. van der Steen, N. de Jong

Author Affiliations +

Proceedings Volume 8320, Medical Imaging 2012: Ultrasonic Imaging, Tomography, and Therapy; 83200W (2012) https://doi.org/10.1117/12.912461
Event: SPIE Medical Imaging, 2012, San Diego, California, United States

Abstract

In this work the use of the self-demodulation (S-D) signal as a mean of microbubble excitation at the subharmonic (SH) frequency to enhance the SH emission of ultrasound contrast agent (UCA) is studied. SH emission from the UCA is of interest since it is produced only by the UCA and is free of the artifacts produced in harmonic imaging modes. The S-D wave is a low-frequency signal produced by nonlinear propagation of an ultrasound wave in the medium. Single element transducer experiments and numerical simulations were conducted at 10 MHz to study the effect of the S-D signal on the SH response of the UCA by modifying the envelope of the excitation bursts. For 6 and 20 transmitted cycles, the SH response is increased up to 25 dB and 22 dB because of the S-D stimulation for a burst with a rectangular envelope compared with a Gaussian envelope burst. Such optimized excitations were used in an array-based micro-ultrasound system (Vevo 2100, VisualSonics Inc., Toronto, ON, Canada) at 18 MHz for in vitro validation of SH imaging. This study suggests that a suitable design of the envelope of the transmit excitation to generate a S-D signal at the SH frequency can enhance the SH emission of UCA and real-time SH imaging is feasible with shorter transmit burst (6- cycle) and low acoustic pressure (~150 KPa) at high frequencies (>15 MHz).

Citation Download Citation

V. Daeichin, T. Faez, A. Needles, G. Renaud, J. G. Bosch, A. F. W. van der Steen, and N. de Jong "Self-demodulation effect on subharmonic response of ultrasound contrast agent", Proc. SPIE 8320, Medical Imaging 2012: Ultrasonic Imaging, Tomography, and Therapy, 83200W (24 February 2012); https://doi.org/10.1117/12.912461

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

;

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE