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13 March 2012 Surface-enhanced Raman spectroscopy of creatinine in silver colloid
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Surface enhanced Raman spectroscopy (SERS) technology has already made great progress in bio-molecule detection. It can make the target molecules strongly absorbed onto the surface of metal nanoparticles, and then the Raman signal of its own has been greatly enhanced through physical and chemical enhancement mechanisms. We report the SERS spectra of creatinine in silver colloid, and study the silver colloid enhanced effects on the Raman scattering of creatinine. We can also find that creatinine concentration is linearly related to its SERS peak intensity and the detection limit of creatinine silver sol is found to be 10 mg/dl. In conclusion, we can observe that the silver colloid has very good enhanced effects for the creatinine. The potential applications of SERS in quantitative measurement of the creatinine liquor are demonstrated. The result shows that the SERS approach would provide a unique and fast test method for creatinine detection.
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Yue Wang, Jiesi Chen, Yanan Wu, Yanping Chen, Jianji Pan, Jinping Lei, Yongjian Chen, Liqing Sun, Shangyuan Feng, and Rong Chen "Surface-enhanced Raman spectroscopy of creatinine in silver colloid", Proc. SPIE 8329, Tenth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2011), 83290K (13 March 2012);

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