Dual-modal (OIS/LSCI) imager of cerebral cortex in freely moving animals

Hongyang Lu; Peng Miao; Qi Liu; Yao Li; Shanbao Tong

doi:10.1117/12.919133

13 March 2012 Dual-modal (OIS/LSCI) imager of cerebral cortex in freely moving animals

Hongyang Lu, Peng Miao, Qi Liu, Yao Li, Shanbao Tong

Proceedings Volume 8329, Tenth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2011); 83290P (2012) https://doi.org/10.1117/12.919133
Event: Photonics and Optoelectronics Meetings 2011, 2011, Wuhan, China

Abstract

Optical intrinsic signals (OIS) and laser speckle contrast imaging (LSCI) have been used for years in the study of the cerebral blood flow (CBF) and hemodynamic responses to the neural activity under functional stimulation. So far, most in vivo rodent experiments are based on the anesthesia model when the animals are in unconscious and restrained conditions. The influences of anesthesia on the neural activity have been documented in literature. In this study, we designed a miniature head-mounted dual-modal imager in freely moving animals that could monitor in real time the coupling of local oxygen consumption and blood perfusion of CBF by integrating different imaging modalities of OIS and LSCI. The system facilitates the study the cortical hemodynamics and neural-hemodynamic coupling in real time in freely moving animals.

Citation Download Citation

Hongyang Lu, Peng Miao, Qi Liu, Yao Li, and Shanbao Tong "Dual-modal (OIS/LSCI) imager of cerebral cortex in freely moving animals", Proc. SPIE 8329, Tenth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2011), 83290P (13 March 2012); https://doi.org/10.1117/12.919133

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