Conformational characteristics of chiral and racemic naproxen molecules investigated by terahertz time-domain spectroscopy

Yong Du; Rongjiao Zhao; Guohui Hao; Changsheng Guo; Zhi Hong

doi:10.1117/12.918840

13 March 2012 Conformational characteristics of chiral and racemic naproxen molecules investigated by terahertz time-domain spectroscopy

Yong Du, Rongjiao Zhao, Guohui Hao, Changsheng Guo, Zhi Hong

Author Affiliations +

Proceedings Volume 8330, Photonics and Optoelectronics Meetings (POEM) 2011: Laser and Terahertz Science and Technology; 83300X (2012) https://doi.org/10.1117/12.918840
Event: Photonics and Optoelectronics Meetings 2011, 2011, Wuhan, China

Abstract

Absorption spectra in the terahertz region between 6 and 66 cm^-1 (0.2 ~ 2.0 THz) were measured for S-(+)-, R-(-) and RS-naproxen pharmaceutical molecules in crystalline form using time-domain terahertz spectroscopic (THz-TDS) technique at room temperature. Different absorption features were observed for the racemic RS-naproxen and its corresponding enantiomers (S-(+)- and R-(-)-naproxen). The observed THz absorption bands are strikingly sensitive to the change of subtle conformational structures despite that the isostructurality exists within such crystal molecules. The results show that the THz-TDS technique can be definitely used for distinguishing between chiral and racemic compounds in pharmaceutical and biological fields.

Citation Download Citation

Yong Du, Rongjiao Zhao, Guohui Hao, Changsheng Guo, and Zhi Hong "Conformational characteristics of chiral and racemic naproxen molecules investigated by terahertz time-domain spectroscopy", Proc. SPIE 8330, Photonics and Optoelectronics Meetings (POEM) 2011: Laser and Terahertz Science and Technology, 83300X (13 March 2012); https://doi.org/10.1117/12.918840

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