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8 May 2012 Layered polymer: inorganic composite waveguides for biosensor applications
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Abstract
In this work, we investigate the usability of layered polymer - inorganic composite waveguides for label-free sensing of surface bound bioreactions in an aqueous environment. The waveguide structure consists of a nanoimprint fabricated polymeric inverted rib waveguide with a sputtered Ta2O5 thin film on top. The interaction of the optical field with the surface is increased as a consequence of the mode profile localization near the surface, when high-index coating is deposited on a low-index waveguide. Young interferometer configuration with reference and sensors waveguide arms was utilized in sensor chips. Light from a laser source was end-fire coupled into the chips and interference pattern produced by the outcoupled light was investigated. External μ-fluidic pump was used to produce the analyte flow. Ambient refractive index change was characterized by applying DI-water with varying glucose concentration on waveguides. With the waveguide length of 1 cm a detection limit in the order of 10-7 - 10-6 refractive index unit (RIU) was achieved. Specific binding reactions on the surface were investigated with C - reactive protein (CRP) antibodies and antigens.
© (2012) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Jussi Hiltunen, Meng Wang, Christina Liedert, Sanna Aikio, Noriyuki Masuda, Stuart Pearce, Martin Charlton, and Pentti Karioja "Layered polymer: inorganic composite waveguides for biosensor applications", Proc. SPIE 8427, Biophotonics: Photonic Solutions for Better Health Care III, 84270I (8 May 2012); https://doi.org/10.1117/12.922267
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