Toluidine blue O-conjugated gold nanoparticles for photodynamic therapy of cultured colon cancer

Rasoul Al-Majmaie; Nebras Alattar; Dominic Zerulla; Mohamed Al-Rubeai

doi:10.1117/12.921813

8 May 2012 Toluidine blue O-conjugated gold nanoparticles for photodynamic therapy of cultured colon cancer

Rasoul Al-Majmaie, Nebras Alattar, Dominic Zerulla, Mohamed Al-Rubeai

Proceedings Volume 8427, Biophotonics: Photonic Solutions for Better Health Care III; 842722 (2012) https://doi.org/10.1117/12.921813
Event: SPIE Photonics Europe, 2012, Brussels, Belgium

Abstract

Photodynamic therapy (PDT) is an emerging technique for the treatment of cancerous and non-cancerous conditions. Gold nanoparticles (GNPs) possess unique physical and chemical properties which allow them to act as multifunctional agents in nanomedicine. GNP- photosensitizer conjugates have attracted increasing attention in drug delivery for photodynamic cancer therapy. In the present investigation, we prepared covalent conjugates of the photosensitizer Toluidine Blue O (TBO) and thiol protected GNPs. The suitability of TBO- GNPs conjugates for in vitro PDT was assayed using the SW480 Human colon adenocarcinoma cell line. Our results suggest that gold nanoparticle conjugates are an excellent vehicle for delivery of photosensitizer agents in the photodynamic therapy of cultured tumour cells.

Citation Download Citation

Rasoul Al-Majmaie, Nebras Alattar, Dominic Zerulla, and Mohamed Al-Rubeai "Toluidine blue O-conjugated gold nanoparticles for photodynamic therapy of cultured colon cancer", Proc. SPIE 8427, Biophotonics: Photonic Solutions for Better Health Care III, 842722 (8 May 2012); https://doi.org/10.1117/12.921813

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