Accurate determination of the complex refractive index of solid tissue-equivalent phantom

Jin Wang; Qing Ye; Zhichao Deng; Wenyuan Zhou; Chunping Zhang; Jianguo Tian

doi:10.1117/12.919832

8 May 2012 Accurate determination of the complex refractive index of solid tissue-equivalent phantom

Jin Wang, Qing Ye, Zhichao Deng, Wenyuan Zhou, Chunping Zhang, Jianguo Tian

Proceedings Volume 8427, Biophotonics: Photonic Solutions for Better Health Care III; 842729 (2012) https://doi.org/10.1117/12.919832
Event: SPIE Photonics Europe, 2012, Brussels, Belgium

Abstract

Tissue-equivalent phantom is becoming widespread as a substitute in the biological field to verify optical theories, test measuring systems and study the tissue performances for varying boundary conditions, sample size and shape at a quantitative level. Compared with phantoms made with Intralipid solution, ink and other liquid substances, phantom in solid state is stable over time, reproducible, easy to handle and has been testified to be a suitable optical simulator in the visible and near-infrared region. We present accurate determination of the complex refractive index (RI) of a solid tissueequivalent phantom using extended derivative total reflection method (EDTRM). Scattering phantoms in solid state were measured for p-polarized and s-polarized incident light respectively. The reflectance curves of the sample as a function of incident angle were recorded. The real part of RI is directly determined by derivative of the reflectance curve, and the imaginary part is obtained from nonlinear fitting based on the Fresnel equation and Nelder-Mead simplex method. The EDTRM method is applicable for RI measurement of high scattering media such as biotissue, solid tissue-equivalent phantom and bulk material. The obtained RI information can be used in the study of tissue optics and biomedical field.

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Jin Wang, Qing Ye, Zhichao Deng, Wenyuan Zhou, Chunping Zhang, and Jianguo Tian "Accurate determination of the complex refractive index of solid tissue-equivalent phantom", Proc. SPIE 8427, Biophotonics: Photonic Solutions for Better Health Care III, 842729 (8 May 2012); https://doi.org/10.1117/12.919832

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KEYWORDS

Refractive index

Reflectivity

Tissue optics

Silicon

Scattering

Optical testing

Tissues

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