Structure And Properties Of Novel Benzo[a]phenoxazinium Photochemotherapeutic Agents

James W. Foley; Louis Cincotta; Anthony H. Cincotta

doi:10.1117/12.942694

19 February 1988 Structure And Properties Of Novel Benzo[a]phenoxazinium Photochemotherapeutic Agents

James W. Foley, Louis Cincotta, Anthony H. Cincotta

Proceedings Volume 0847, New Directions in Photodynamic Therapy; (1988) https://doi.org/10.1117/12.942694
Event: Cambridge Symposium on Optics in Medicine and Visual Image Processing, 1987, San Diego, CA, United States

Abstract

The approach used for the development of some novel benzophenoxazinium photosensitizers is presented. Considerations that have influenced the design of these dyes include structure/function relationships pertaining to such properties as selective tumor staining, fluorescent quantum yields and photosensitized singlet oxygen formation (1O2). General trends in the relative photodynamic behavior exhibited by these new dyes in cell culture are discussed. The results indicate that several of the dyes have significant photosensitizing efficacy.

Citation Download Citation

James W. Foley, Louis Cincotta, and Anthony H. Cincotta "Structure And Properties Of Novel Benzo[a]phenoxazinium Photochemotherapeutic Agents", Proc. SPIE 0847, New Directions in Photodynamic Therapy, (19 February 1988); https://doi.org/10.1117/12.942694

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