Laminated cubic biodegradable polymer structures for bacteria-based, robotic drug delivery

Hyung Jung Yoo; Sangmin Lee; Jae Hyun Ahn; Seok-jun Hong; Minjae Lee; Jong Mo Seo; Tae You Kim; Sung Jae Kim; Dong-il "Dan" Cho

doi:10.1117/12.2000219

24 October 2012 Laminated cubic biodegradable polymer structures for bacteria-based, robotic drug delivery

Hyung Jung Yoo, Sangmin Lee, Jae Hyun Ahn, Seok-jun Hong, Minjae Lee, Jong Mo Seo, Tae You Kim, Sung Jae Kim, Dong-il "Dan" Cho

Author Affiliations +

Proceedings Volume 8548, Nanosystems in Engineering and Medicine; 85483S (2012) https://doi.org/10.1117/12.2000219
Event: SPIE Nanosystems in Engineering + Medicine, 2012, Incheon, Korea, Republic of

Abstract

Recently, a bacteria-based drug delivery system has been proposed to achieve effective and localized drug delivery. Researchers have shown that flagellated bacteria have a chemotactic property to tumor cells, and they can be used as an energy source for active drug delivery. Our previous results have reported that a circular droplet made by a biodegradable polymer can be used in this bacteria-based, robotic drug delivery. In this paper, using laminated cubic structures made of several layers of biodegradable polymers for bacteria-based microrobot is proposed. The structures are made by laminating polymer layers and then, micromachining them using a deep X-ray synchrotron radiation into 40 μm x 40 μm x 40 μm cubes. The cubic structure is more beneficial in attaching bacteria in only selective surface directions than a circular structure, and in controlling the volume of drugs to be encapsulated with the outer polymer layer.

Citation Download Citation

Hyung Jung Yoo, Sangmin Lee, Jae Hyun Ahn, Seok-jun Hong, Minjae Lee, Jong Mo Seo, Tae You Kim, Sung Jae Kim, and Dong-il "Dan" Cho "Laminated cubic biodegradable polymer structures for bacteria-based, robotic drug delivery", Proc. SPIE 8548, Nanosystems in Engineering and Medicine, 85483S (24 October 2012); https://doi.org/10.1117/12.2000219

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