Nonlinear optical imaging characteristics of colonic adenocarcinoma using multiphoton microscopy

Nenrong Liu; Rong Chen; Hongsheng Li; Jianxin Chen

doi:10.1117/12.999860

11 December 2012 Nonlinear optical imaging characteristics of colonic adenocarcinoma using multiphoton microscopy

Nenrong Liu, Rong Chen, Hongsheng Li, Jianxin Chen

Proceedings Volume 8553, Optics in Health Care and Biomedical Optics V; 855318 (2012) https://doi.org/10.1117/12.999860
Event: Photonics Asia, 2012, Beijing, China

Abstract

Multiphoton microscopy (MPM), a noninvasive optical method with high resolution and high sensitivity, can obtain detailed microstructures of biotissues at submolecular level. In this study, MPM is used to image microstructure varieties of human colonic mucosa and submucosa with adenocarcinoma. Some parameters, such as gland configuration, SHG/TPEF intensity ratio, and collagen orientation and so on, should serve the indicators of early colorectal cancer. The exploratory results show that it's potential for the development of multiphoton mini-endoscopy in real-time early diagnosis of colorectal cancer.

Citation Download Citation

Nenrong Liu, Rong Chen, Hongsheng Li, and Jianxin Chen "Nonlinear optical imaging characteristics of colonic adenocarcinoma using multiphoton microscopy", Proc. SPIE 8553, Optics in Health Care and Biomedical Optics V, 855318 (11 December 2012); https://doi.org/10.1117/12.999860

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