Modeling stromal determinants of 3D tumor growth to inform PDT-mediated combination treatments

I. Rizvi; S. Anbil; J. P. Celli; N. Alagic; I. Massodi; T. Hasan

doi:10.1117/12.2010678

13 March 2013 Modeling stromal determinants of 3D tumor growth to inform PDT-mediated combination treatments

I. Rizvi, S. Anbil, J. P. Celli, N. Alagic, I. Massodi, T. Hasan

Proceedings Volume 8568, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXII; 85680H (2013) https://doi.org/10.1117/12.2010678
Event: SPIE BiOS, 2013, San Francisco, California, United States

Abstract

Advanced stage ovarian carcinoma is characterized by poor prognosis and peritoneal micronodules that exhibit treatment resistance. This is partially due to interactions between multifocal disease and the tumor microenvironment, which includes tumor endothelial cells (TECs) and extracellular matrix components (ECM). Here we describe the development of a three-dimensional model of ovarian cancer that incorporates TECs and ECM. A comparison of several methodologies to generate endothelialized ovarian micronodules along with a preliminary physical characterization is described. This model will allow for detailed investigation of tumor-stroma interactions and how they impact disease progression and treatment response.

Citation Download Citation

I. Rizvi, S. Anbil, J. P. Celli, N. Alagic, I. Massodi, and T. Hasan "Modeling stromal determinants of 3D tumor growth to inform PDT-mediated combination treatments", Proc. SPIE 8568, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXII, 85680H (13 March 2013); https://doi.org/10.1117/12.2010678

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available