Dual-wavelength photothermal optical coherence tomography for blood oxygen saturation measurement

Biwei Yin; Roman V. Kuranov; Austin B. McElroy; Thomas E. Milner

doi:10.1117/12.2006945

20 March 2013 Dual-wavelength photothermal optical coherence tomography for blood oxygen saturation measurement

Biwei Yin, Roman V. Kuranov, Austin B. McElroy, Thomas E. Milner

Proceedings Volume 8571, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVII; 857103 (2013) https://doi.org/10.1117/12.2006945
Event: SPIE BiOS, 2013, San Francisco, California, United States

Abstract

We report design and demonstration of a dual wavelength photothermal (DWP) optical coherence tomography (OCT) system for imaging of a phantom microvessel and measurement of hemoglobin oxygen saturation (SO₂) level. The DWP-OCT system contains a swept-source (SS) two-beam phase-sensitive (PhS) OCT system (1060 nm) and two intensity modulated photothermal excitation lasers (770 nm and 800 nm). The PhS-OCT probe beam (1060 nm) and photothermal excitation beams are combined into one single-mode optical fiber. A galvanometer based two-dimensional achromatic scanning system is designed to provide 14 μm lateral resolution for the PhS-OCT probe beam (1060 nm) and 13 μm lateral resolution for photothermal excitation beams. DWP-OCT system’s sensitivity is 102 dB, axial resolution is 13 μm in tissue and uses a real-time digital dispersion compensation algorithm. Noise floor for optical pathlength measurements is 300 pm in the signal frequency range (380-400 Hz) of photothermal modulation frequencies. Blood SO₂ level is calculated from measured optical pathlength (op) signal in a 300 μm diameter microvessel phantom introduced by the two photothermal excitation beams. En-face and B-scan images of a phantom microvessel are recorded, and six blood samples’ SO₂ levels are measured using DWP-OCT and compared with values provided by a commercial blood oximeter. A mathematical model indicates thermal diffusion introduces a systematic artifact that over-estimates SO₂ values and is consistent with measured data.

Citation Download Citation

Biwei Yin, Roman V. Kuranov, Austin B. McElroy, and Thomas E. Milner "Dual-wavelength photothermal optical coherence tomography for blood oxygen saturation measurement", Proc. SPIE 8571, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVII, 857103 (20 March 2013); https://doi.org/10.1117/12.2006945

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