Toward ideal imaging geometry for recovery independence in fluorescence molecular tomography

Robert W. Holt; Frederic Leblond; Brian W. Pogue

doi:10.1117/12.2004870

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13 March 2013 Toward ideal imaging geometry for recovery independence in fluorescence molecular tomography

Robert W. Holt, Frederic Leblond, Brian W. Pogue

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Proceedings Volume 8574, Multimodal Biomedical Imaging VIII; 857403 (2013) https://doi.org/10.1117/12.2004870
Event: SPIE BiOS, 2013, San Francisco, California, United States

Abstract

An established challenge with fluorescence molecular tomography is inconsistent accuracy in quantifying recovered fluorescent contrast with changes in target depth. This work examines the idea that through optimization of the source and detector placement more consistent contrast could be recovered regardless of imaging depth. A simulation study was performed to examine distributions of optical projection measurements result in a uniform summed sensitivity function, showing that half-reflectance and transmission measurements are the most important for accurate and consistent target recovery as a function of depth. As a corollary to the importance of uniform summed sensitivity, translation modulated reconstructions are shown to provide improvements in fluorescence tomography.

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Robert W. Holt, Frederic Leblond, and Brian W. Pogue "Toward ideal imaging geometry for recovery independence in fluorescence molecular tomography", Proc. SPIE 8574, Multimodal Biomedical Imaging VIII, 857403 (13 March 2013); https://doi.org/10.1117/12.2004870

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