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13 March 2013 Toward ideal imaging geometry for recovery independence in fluorescence molecular tomography
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Proceedings Volume 8574, Multimodal Biomedical Imaging VIII; 857403 (2013)
Event: SPIE BiOS, 2013, San Francisco, California, United States
An established challenge with fluorescence molecular tomography is inconsistent accuracy in quantifying recovered fluorescent contrast with changes in target depth. This work examines the idea that through optimization of the source and detector placement more consistent contrast could be recovered regardless of imaging depth. A simulation study was performed to examine distributions of optical projection measurements result in a uniform summed sensitivity function, showing that half-reflectance and transmission measurements are the most important for accurate and consistent target recovery as a function of depth. As a corollary to the importance of uniform summed sensitivity, translation modulated reconstructions are shown to provide improvements in fluorescence tomography.
© (2013) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Robert W. Holt, Frederic Leblond, and Brian W. Pogue "Toward ideal imaging geometry for recovery independence in fluorescence molecular tomography", Proc. SPIE 8574, Multimodal Biomedical Imaging VIII, 857403 (13 March 2013);

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