Detecting fluorescence hot-spots using mosaic maps generated from multimodal endoscope imaging

Chenying Yang; Timothy D. Soper; Eric J. Seibel

doi:10.1117/12.2002219

13 March 2013 Detecting fluorescence hot-spots using mosaic maps generated from multimodal endoscope imaging

Chenying Yang, Timothy D. Soper, Eric J. Seibel

Proceedings Volume 8575, Endoscopic Microscopy VIII; 857508 (2013) https://doi.org/10.1117/12.2002219
Event: SPIE BiOS, 2013, San Francisco, California, United States

Abstract

Fluorescence labeled biomarkers can be detected during endoscopy to guide early cancer biopsies, such as high-grade dysplasia in Barrett's Esophagus. To enhance intraoperative visualization of the fluorescence hot-spots, a mosaicking technique was developed to create full anatomical maps of the lower esophagus and associated fluorescent hot-spots. The resultant mosaic map contains overlaid reflectance and fluorescence images. It can be used to assist biopsy and document findings. The mosaicking algorithm uses reflectance images to calculate image registration between successive frames, and apply this registration to simultaneously acquired fluorescence images. During this mosaicking process, the fluorescence signal is enhanced through multi-frame averaging. Preliminary results showed that the technique promises to enhance the detectability of the hot-spots due to enhanced fluorescence signal.

Citation Download Citation

Chenying Yang, Timothy D. Soper, and Eric J. Seibel "Detecting fluorescence hot-spots using mosaic maps generated from multimodal endoscope imaging ", Proc. SPIE 8575, Endoscopic Microscopy VIII, 857508 (13 March 2013); https://doi.org/10.1117/12.2002219

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available