Monitoring of the degradation in the rat's articular cartilage inducing osteoarthritis using common-path Fourier-domain optical coherence tomography

D. H. Shin; S. H. Park; B. Y. Kim; M. Y. Lee; H. K. Baik; J. H. Seo; J. U. Kang; C. G. Song

doi:10.1117/12.2006463

20 March 2013 Monitoring of the degradation in the rat's articular cartilage inducing osteoarthritis using common-path Fourier-domain optical coherence tomography

D. H. Shin, S. H. Park, B. Y. Kim, M. Y. Lee, H. K. Baik, J. H. Seo, J. U. Kang, C. G. Song

Author Affiliations +

Proceedings Volume 8576, Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications XIII; 85760Z (2013) https://doi.org/10.1117/12.2006463
Event: SPIE BiOS, 2013, San Francisco, California, United States

Abstract

The objective of this experiment is to evaluate the utility and limitations of optical coherence tomography (OCT) for real-time, high-resolution structural analysis. We monitored the degradation of the rat’s articular cartilage inducing osteoarthritis (OA) and the change of the rat’s articular cartilage recovery by treatment medication, using our developed common-path Fourier-domain (CP-FD) OCT. Also, we have done a comparative analysis the rat’s articular cartilage and OA grade. To observe the progression of OA, we induced OA by injecting the monosodium iodoacetate (MIA) into the right knee joint. After the injection of MIA, we sacrificed the rats at intervals of 3 days and obtained OCT and histological images. OCT and histological images showed the OA progress of similar pattern. These results illustrated the potential for non-invasive diagnosis about the grade of OA using CP-FD OCT.

Citation Download Citation

D. H. Shin, S. H. Park, B. Y. Kim, M. Y. Lee, H. K. Baik, J. H. Seo, J. U. Kang, and C. G. Song "Monitoring of the degradation in the rat's articular cartilage inducing osteoarthritis using common-path Fourier-domain optical coherence tomography", Proc. SPIE 8576, Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications XIII, 85760Z (20 March 2013); https://doi.org/10.1117/12.2006463

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
6 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY

GET CITATION

RIGHTS & PERMISSIONS

Get copyright permission Get copyright permission on Copyright Marketplace

KEYWORDS

Optical coherence tomography

Cartilage

Imaging systems

Bone

Magnetic resonance imaging

Optical fibers

Biopsy

Show All Keywords

Keywords/Phrases

Search In:

Publication Years