Moving Raman spectroscopy into real-time, online diagnosis and detection of precancer and cancer in vivo in the upper GI during clinical endoscopic examination

Zhiwei Huang; Mads Sylvest Bergholt; Wei Zheng; Khek Yu Ho; Khay Guan Yeoh; Ming Teh; Jimmy Bok Yan So; Asim Shabbir

doi:10.1117/12.2005697

19 March 2013 Moving Raman spectroscopy into real-time, online diagnosis and detection of precancer and cancer in vivo in the upper GI during clinical endoscopic examination

Zhiwei Huang, Mads Sylvest Bergholt, Wei Zheng, Khek Yu Ho, Khay Guan Yeoh, Ming Teh, Jimmy Bok Yan So, Asim Shabbir

Author Affiliations +

Proceedings Volume 8577, Optical Biopsy XI; 85770G (2013) https://doi.org/10.1117/12.2005697
Event: SPIE BiOS, 2013, San Francisco, California, United States

Abstract

A rapid image-guided Raman endoscopy system integrated with on-line diagnostic scheme is developed for in vivo Raman tissue diagnosis (optical biopsy) in the upper GI during clinical gastrointestinal endoscopy under multimodal wide-field imaging guidance. The real-time Raman endoscopy technique was tested prospectively on new gastric patients (n=4) and could identify dysplasia in vivo with sensitivity of 81.5% (22/27) and specificity of 87.9% (29/33). This study realizes for the first time the novel image-guided Raman endoscopy as a screening tool for real-time, online diagnosis of gastric cancer and precancer in vivo at endoscopy.

Citation Download Citation

Zhiwei Huang, Mads Sylvest Bergholt, Wei Zheng, Khek Yu Ho, Khay Guan Yeoh, Ming Teh, Jimmy Bok Yan So, and Asim Shabbir "Moving Raman spectroscopy into real-time, online diagnosis and detection of precancer and cancer in vivo in the upper GI during clinical endoscopic examination", Proc. SPIE 8577, Optical Biopsy XI, 85770G (19 March 2013); https://doi.org/10.1117/12.2005697

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