Vibration-based photoacoustic tomography

Rui Li; Justin Rajesh Rajian; Pu Wang; Mikhail N. Slipchenko; Ji-Xin Cheng

doi:10.1117/12.2001571

4 March 2013 Vibration-based photoacoustic tomography

Rui Li, Justin Rajesh Rajian, Pu Wang, Mikhail N. Slipchenko, Ji-Xin Cheng

Proceedings Volume 8581, Photons Plus Ultrasound: Imaging and Sensing 2013; 85811M (2013) https://doi.org/10.1117/12.2001571
Event: SPIE BiOS, 2013, San Francisco, California, United States

Abstract

Photoacoustic imaging employing molecular overtone vibration as contrast mechanism opens a new avenue for deep tissue imaging with chemical bond selectivity. Here, we demonstrate vibration-based photoacoustic tomography with an imaging depth on the centimeter scale. To provide sufficient pulse energy at the overtone transition wavelengths, we constructed a compact, barium nitrite crystal-based Raman laser for excitation of 2^nd overtone of C-H bond. Using a 5-ns Nd:YAG laser as pumping source, up to 105 mJ pulse energy at 1197 nm was generated. Vibrational photoacoutic spectroscopy and tomography of phantom (polyethylene tube) immersed in whole milk was performed. With a pulse energy of 47 mJ on the milk surface, up to 2.5 cm penetration depth was reached with a signal-to-noise ratio of 12.

Citation Download Citation

Rui Li, Justin Rajesh Rajian, Pu Wang, Mikhail N. Slipchenko, and Ji-Xin Cheng "Vibration-based photoacoustic tomography", Proc. SPIE 8581, Photons Plus Ultrasound: Imaging and Sensing 2013, 85811M (4 March 2013); https://doi.org/10.1117/12.2001571

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KEYWORDS

Raman spectroscopy

Crystals

Laser crystals

Photoacoustic tomography

Nd:YAG lasers

Signal detection

Tomography

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