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4 March 2013Single wall carbon nanotube/bis carboxylic acid-ICG as a
sensitive contrast agent for in vivo tumor imaging in
photoacoustic tomography
In this study, we present a novel photoacoustic contrast agent which is based on bis-carboxylic acid
derivative of Indocyanine green (ICG) covalently conjugated to single-wall carbon nanotubes
(ICG/SWCNT). Covalently attaching ICG to the functionalized SWCNT provides a more robust system
that delivers much more ICG to the tumor site. The detection sensitivity of the new contrast agent in
mouse tumor model is demonstrated in vivo by our custom built photoacoustic imaging system. PAT
summation signal is defined to show the long-term light absorption of tumor areas in ICG injected mice and
ICG/SWCNT injected mice. It is shown that ICG is able to provide 33% enhancement at approximately 20
minutes peak response time referred to pre-injection PAT summation level, while ICG/SWCNT provides
128% enhancement at 80 minutes and even higher enhancement of 196% at the end point of experiments
(120 minutes on average). Additionally, the ICG/SWCNT enhancement was mainly observed at the tumor
periphery as confirmed by fluorescence images of the tumor samples. This feature is highly valuable in
guiding surgeons to assess tumor boundaries and dimensions in vivo and improve surgical resection of
tumors for achieving clean tumor margins.
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Saeid Zanganeh, Hai Li, Patrick Kumavor, Umar Alqasemi, Andres Aguirre, Innus Mohammad, Courtney Stanford, Michael B. Smith, Quing Zhu, "Single wall carbon nanotube/bis carboxylic acid-ICG as a
sensitive contrast agent for in vivo tumor imaging in
photoacoustic tomography," Proc. SPIE 8581, Photons Plus Ultrasound: Imaging and Sensing 2013, 85814R (4 March 2013); https://doi.org/10.1117/12.2008179