Wide-field microscopy using microcamera arrays

Daniel L. Marks; Seo Ho Youn; Hui S. Son; Jungsang Kim; David J. Brady

doi:10.1117/12.2002860

22 February 2013 Wide-field microscopy using microcamera arrays

Daniel L. Marks, Seo Ho Youn, Hui S. Son, Jungsang Kim, David J. Brady

Proceedings Volume 8589, Three-Dimensional and Multidimensional Microscopy: Image Acquisition and Processing XX; 85890Z (2013) https://doi.org/10.1117/12.2002860
Event: SPIE BiOS, 2013, San Francisco, California, United States

Abstract

A microcamera is a relay lens paired with image sensors. Microcameras are grouped into arrays to relay overlapping views of a single large surface to the sensors to form a continuous synthetic image. The imaged surface may be curved or irregular as each camera may independently be dynamically focused to a different depth. Microcamera arrays are akin to microprocessors in supercomputers in that both join individual processors by an optoelectronic routing fabric to increase capacity and performance. A microcamera may image ten or more megapixels and grouped into an array of several hundred, as has already been demonstrated by the DARPA AWARE Wide-Field program with multiscale gigapixel photography. We adapt gigapixel microcamera array architectures to wide-field microscopy of irregularly shaped surfaces to greatly increase area imaging over 1000 square millimeters at resolutions of 3 microns or better in a single snapshot. The system includes a novel relay design, a sensor electronics package, and a FPGA-based networking fabric. Biomedical applications of this include screening for skin lesions, wide-field and resolution-agile microsurgical imaging, and microscopic cytometry of millions of cells performed in situ.

Citation Download Citation

Daniel L. Marks, Seo Ho Youn, Hui S. Son, Jungsang Kim, and David J. Brady "Wide-field microscopy using microcamera arrays", Proc. SPIE 8589, Three-Dimensional and Multidimensional Microscopy: Image Acquisition and Processing XX, 85890Z (22 February 2013); https://doi.org/10.1117/12.2002860

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