Self-referenced silicon nitride array microring biosensor for toxin detection using glycans at visible wavelength

Farshid Ghasemi; Ali A. Eftekhar; David S. Gottfried; Xuezheng Song; Richard D. Cummings; Ali Adibi

doi:10.1117/12.2005653

19 February 2013 Self-referenced silicon nitride array microring biosensor for toxin detection using glycans at visible wavelength

Farshid Ghasemi, Ali A. Eftekhar, David S. Gottfried, Xuezheng Song, Richard D. Cummings, Ali Adibi

Author Affiliations +

Proceedings Volume 8594, Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications X; 85940A (2013) https://doi.org/10.1117/12.2005653
Event: SPIE BiOS, 2013, San Francisco, California, United States

Abstract

We report on application of on-chip referencing to improve the limit-of-detection (LOD) in compact silicon nitride (SiN) microring arrays. Microring resonators, fabricated by e-beam lithography and fluorine-based etching, are designed for visible wavelengths (656nm) and have a footprint of 20 x 20 μm. GM1 ganglioside is used as the specific ligand for recognition of Cholera Toxin Subunit B (CTB), with Ricinus Communis Agglutinin I (RCA I) as a negative control. Using micro-cantilever based printing less than 10 pL of glycan solution is consumed per microring. Real-time data on analyte binding is extracted from the shifts in resonance wavelengths of the microrings.

Citation Download Citation

Farshid Ghasemi, Ali A. Eftekhar, David S. Gottfried, Xuezheng Song, Richard D. Cummings, and Ali Adibi "Self-referenced silicon nitride array microring biosensor for toxin detection using glycans at visible wavelength", Proc. SPIE 8594, Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications X, 85940A (19 February 2013); https://doi.org/10.1117/12.2005653

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