A portable instrument for continuous glucose monitoring by the integration of microfluidic chip and micro-glucose sensor

Dachao Li; Yongjie Ji; Wenshuai Liang; Xiaoli Zhang; Haixia Yu; Kexin Xu

doi:10.1117/12.2003535

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9 March 2013 A portable instrument for continuous glucose monitoring by the integration of microfluidic chip and micro-glucose sensor

Dachao Li, Yongjie Ji, Wenshuai Liang, Xiaoli Zhang, Haixia Yu, Kexin Xu

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Proceedings Volume 8615, Microfluidics, BioMEMS, and Medical Microsystems XI; 861519 (2013) https://doi.org/10.1117/12.2003535
Event: SPIE MOEMS-MEMS, 2013, San Francisco, California, United States

Abstract

Interstitial fluid (ISF) can be transdermally extracted using low-frequency ultrasound and continuous vacuum pressure on skin surface. But the tiny volume of transdermally extracted ISF makes the transdermal extraction, collection, transport, volumetric detection and glucose concentration measurement of the ISF very difficult. Based on a microfluidic chip for transdermally extraction of interstitial fluid and a micro glucose sensor for glucose concentration measurement, a continuous glucose monitoring instrumentby ISF transdermal extraction with minimally invasive way is developed. In the paper, various parts of the device and their interface circuits are designed; the hardware and software of the instrument are built; the simulating experiments of transdermal ISF extraction, collection and volume measurement with full-thickness pig skin are performed using this integrated system; and the functionalities of this device is verified for future clinical application.

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Dachao Li, Yongjie Ji, Wenshuai Liang, Xiaoli Zhang, Haixia Yu, and Kexin Xu "A portable instrument for continuous glucose monitoring by the integration of microfluidic chip and micro-glucose sensor", Proc. SPIE 8615, Microfluidics, BioMEMS, and Medical Microsystems XI, 861519 (9 March 2013); https://doi.org/10.1117/12.2003535

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