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6 March 2013 Optimization of clinical protocols for contrast enhanced breast imaging
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Proceedings Volume 8668, Medical Imaging 2013: Physics of Medical Imaging; 86680G (2013)
Event: SPIE Medical Imaging, 2013, Lake Buena Vista (Orlando Area), Florida, United States
Contrast enhanced (CE) breast imaging has been proposed as a method to increase the sensitivity and specificity of breast cancer detection. Because malignant lesions often exhibit angiogenesis, the uptake of radio-opaque contrast agents (e.g. iodine) results in increased attenuation compared to the background tissue. Both planar CE digital mammography (CE-DM) and digital breast tomosynthesis (CE-DBT) have been proposed, using temporal or dual energy (DE) subtraction to remove tissue backgrounds. In the current study, we apply a cascaded linear systems model approach to analyze CE techniques with DE subtraction for designing a diagnostic imaging study, including the effects of contrast dynamics. We apply the model for both CE-DM and CE-DBT to calculate the ideal observer signal-to-noise ratio (SNR) for the detection of I contrast objects of different sizes and concentrations. The calculation of this figure-of-merit (FOM) was be used to optimize CE clinical imaging protocols.
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Yue-Houng Hu, David A. Scaduto, and Wei Zhao "Optimization of clinical protocols for contrast enhanced breast imaging", Proc. SPIE 8668, Medical Imaging 2013: Physics of Medical Imaging, 86680G (6 March 2013);

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