Edge illumination and coded-aperture X-ray phase-contrast imaging: increased sensitivity at synchrotrons and lab-based translations into medicine, biology and materials science

M. Endrizzi; P. C. Diemoz; M. B. Szafraniec; C. K. Hagen; T. P. Millard; C. E. Zapata; P. R. T. Munro; K. Ignatyev; M. Marenzana; R. D. Speller; A. Olivo

doi:10.1117/12.2007893

6 March 2013 Edge illumination and coded-aperture X-ray phase-contrast imaging: increased sensitivity at synchrotrons and lab-based translations into medicine, biology and materials science

M. Endrizzi, P. C. Diemoz, M. B. Szafraniec, C. K. Hagen, T. P. Millard, C. E. Zapata, P. R. T. Munro, K. Ignatyev, M. Marenzana, R. D. Speller, A. Olivo

Author Affiliations +

Proceedings Volume 8668, Medical Imaging 2013: Physics of Medical Imaging; 866812 (2013) https://doi.org/10.1117/12.2007893
Event: SPIE Medical Imaging, 2013, Lake Buena Vista (Orlando Area), Florida, United States

Abstract

The edge illumination principle was first proposed at Elettra (Italy) in the late nineties, as an alternative method for achieving high phase sensitivity with a very simple and flexible set-up, and has since been under continuous development in the radiation physics group at UCL. Edge illumination allows overcoming most of the limitations of other phase-contrast techniques, enabling their translation into a laboratory environment. It is relatively insensitive to mechanical and thermal instabilities and it can be adapted to the divergent and polychromatic beams provided by X-ray tubes. This method has been demonstrated to work efficiently with source sizes up to 100m, compatible with state-of-the-art mammography sources. Two full prototypes have been built and are operational at UCL. Recent activity focused on applications such as breast and cartilage imaging, homeland security and detection of defects in composite materials. New methods such as phase retrieval, tomosynthesis and computed tomography algorithms are currently being theoretically and experimentally investigated. These results strongly indicate the technique as an extremely powerful and versatile tool for X-ray imaging in a wide range of applications.

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M. Endrizzi, P. C. Diemoz, M. B. Szafraniec, C. K. Hagen, T. P. Millard, C. E. Zapata, P. R. T. Munro, K. Ignatyev, M. Marenzana, R. D. Speller, and A. Olivo "Edge illumination and coded-aperture X-ray phase-contrast imaging: increased sensitivity at synchrotrons and lab-based translations into medicine, biology and materials science", Proc. SPIE 8668, Medical Imaging 2013: Physics of Medical Imaging, 866812 (6 March 2013); https://doi.org/10.1117/12.2007893

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