Visual analysis of longitudinal brain tumor perfusion

Sylvia Glaßer; Steffen Oeltze; Uta Preim; Atle Bjørnerud; Helwig Hauser; Bernhard Preim

doi:10.1117/12.2007878

28 February 2013 Visual analysis of longitudinal brain tumor perfusion

Sylvia Glaßer, Steffen Oeltze, Uta Preim, Atle Bjørnerud, Helwig Hauser, Bernhard Preim

Proceedings Volume 8670, Medical Imaging 2013: Computer-Aided Diagnosis; 86700Z (2013) https://doi.org/10.1117/12.2007878
Event: SPIE Medical Imaging, 2013, Lake Buena Vista (Orlando Area), Florida, United States

Abstract

In clinical research on diagnosis and evaluation of brain tumors, longitudinal perfusion MRI studies are acquired for tumor grading as well as to monitor and assess treatment response and patient prognosis. Within this work, we demonstrate how visual analysis techniques can be adapted to multidimensional datasets from such studies within a framework to support the computer-aided diagnosis of brain tumors. Our solution builds on two innovations: First, we introduce a pipeline yielding comparative, co-registered quantitative perfusion parameter maps over all time steps of the longitudinal study. Second, based on these time-dependent parameter maps, visual analysis methods were developed and adapted to reveal valuable insight into tumor progression, especially regarding the clinical research area of low grade glioma transformation into high grade gliomas. Our examination of four longitudinal brain studies demonstrates the suitability of the presented visual analysis methods and comprises new possibilities for the clinical researcher to characterize the development of low grade gliomas.

Citation Download Citation

Sylvia Glaßer, Steffen Oeltze, Uta Preim, Atle Bjørnerud, Helwig Hauser, and Bernhard Preim "Visual analysis of longitudinal brain tumor perfusion", Proc. SPIE 8670, Medical Imaging 2013: Computer-Aided Diagnosis, 86700Z (28 February 2013); https://doi.org/10.1117/12.2007878

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