A nonparametric approach for statistical comparison of results from alternative forced choice experiments

Frédéric Noo; Adam Wunderlich; Dominic Heuscher; Katharina Schmitt; Zhicong Yu

doi:10.1117/12.2008154

28 March 2013 A nonparametric approach for statistical comparison of results from alternative forced choice experiments

Frédéric Noo, Adam Wunderlich, Dominic Heuscher, Katharina Schmitt, Zhicong Yu

Proceedings Volume 8673, Medical Imaging 2013: Image Perception, Observer Performance, and Technology Assessment; 86730F (2013) https://doi.org/10.1117/12.2008154
Event: SPIE Medical Imaging, 2013, Lake Buena Vista (Orlando Area), Florida, United States

Abstract

Task-based image quality assessment is a valuable methodology for development, optimization and evaluation of new image formation processes in x-ray computed tomography (CT), as well as in other imaging modalities. A simple way to perform such an assessment is through the use of two (or more) alternative forced choice (AFC) experiments. In this paper, we are interested in drawing statistical inference from outcomes of multiple AFC experiments that are obtained using multiple readers as well as multiple cases. We present a non-parametric covariance estimator for this problem. Then, we illustrate its usefulness with a practical example involving x-ray CT simulations. The task for this example is classification between presence or absence of one lesion with unknown location within a given object. This task is used for comparison of three standard image reconstruction algorithms in x-ray CT using four human observers.

Citation Download Citation

Frédéric Noo, Adam Wunderlich, Dominic Heuscher, Katharina Schmitt, and Zhicong Yu "A nonparametric approach for statistical comparison of results from alternative forced choice experiments", Proc. SPIE 8673, Medical Imaging 2013: Image Perception, Observer Performance, and Technology Assessment, 86730F (28 March 2013); https://doi.org/10.1117/12.2008154

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