Compact and cost effective instrument for detecting drug precursors in different environments based on fluorescence polarization

J. C. Antolín-Urbaneja; I. Eguizabal; N. Briz; A. Dominguez; P. Estensoro; A. Secchi; A. Varriale; S. Di Giovanni; S. D'Auria

doi:10.1117/12.2017257

3 May 2013 Compact and cost effective instrument for detecting drug precursors in different environments based on fluorescence polarization

J. C. Antolín-Urbaneja, I. Eguizabal, N. Briz, A. Dominguez, P. Estensoro, A. Secchi, A. Varriale, S. Di Giovanni, S. D'Auria

Author Affiliations +

Proceedings Volume 8774, Optical Sensors 2013; 87741J (2013) https://doi.org/10.1117/12.2017257
Event: SPIE Optics + Optoelectronics, 2013, Prague, Czech Republic

Abstract

Several techniques for detecting chemical drug precursors have been developed in the last decade. Most of them are able to identify molecules at very low concentration under lab conditions. Other commercial devices are able to detect a fixed number and type of target substances based on a single detection technique providing an absence of flexibility with respect to target compounds. The construction of compact and easy to use detection systems providing screening for a large number of compounds being able to discriminate them with low false alarm rate and high probability of detection is still an open concern. Under CUSTOM project, funded by the European Commission within the FP7, a stand-alone portable sensing device based on multiple techniques is being developed. One of these techniques is based on the LED induced fluorescence polarization to detect Ephedrine and Benzyl Methyl Keton (BMK) as a first approach. This technique is highly selective with respect to the target compounds due to the generation of properly engineered fluorescent proteins which are able to bind the target analytes, as it happens in an “immune-type reaction”. This paper deals with the advances in the design, construction and validation of the LED induced fluorescence sensor to detect BMK analytes. This sensor includes an analysis module based on high performance LED and PMT detector, a fluidic system to dose suitable quantities of reagents and some printed circuit boards, all of them fixed in a small structure (167mm × 193mm × 228mm) with the capability of working as a stand-alone application.

Citation Download Citation

J. C. Antolín-Urbaneja, I. Eguizabal, N. Briz, A. Dominguez, P. Estensoro, A. Secchi, A. Varriale, S. Di Giovanni, and S. D'Auria "Compact and cost effective instrument for detecting drug precursors in different environments based on fluorescence polarization", Proc. SPIE 8774, Optical Sensors 2013, 87741J (3 May 2013); https://doi.org/10.1117/12.2017257

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
11 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY

GET CITATION

RIGHTS & PERMISSIONS

Get copyright permission Get copyright permission on Copyright Marketplace

KEYWORDS

Sensors

Luminescence

Light emitting diodes

Polarization

Electronic filtering

Target detection

Linear filtering

Show All Keywords

Keywords/Phrases

Search In:

Publication Years