Optical coherence tomography assessment of vessel wall degradation in aneurysmatic thoracic aortas

Eusebio Real; Alma Eguizabal; Alejandro Pontón; J. Fernando Val-Bernal; Marta Mayorga; José M. Revuelta; José López-Higuera; Olga M. Conde

doi:10.1117/12.2032592

18 June 2013 Optical coherence tomography assessment of vessel wall degradation in aneurysmatic thoracic aortas

Eusebio Real, Alma Eguizabal, Alejandro Pontón, J. Fernando Val-Bernal, Marta Mayorga, José M. Revuelta, José López-Higuera, Olga M. Conde

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Proceedings Volume 8802, Optical Coherence Tomography and Coherence Techniques VI; 88020G (2013) https://doi.org/10.1117/12.2032592
Event: European Conferences on Biomedical Optics, 2013, Munich, Germany

Abstract

Optical coherence tomographic images of ascending thoracic human aortas from aneurysms exhibit disorders on the smooth muscle cell structure of the media layer of the aortic vessel as well as elastin degradation. Ex-vivo measurements of human samples provide results that correlate with pathologist diagnosis in aneurysmatic and control aortas. The observed disorders are studied as possible hallmarks for aneurysm diagnosis. To this end, the backscattering profile along the vessel thickness has been evaluated by fitting its decay against two different models, a third order polynomial fitting and an exponential fitting. The discontinuities present on the vessel wall on aneurysmatic aortas are slightly better identified with the exponential approach. Aneurysmatic aortic walls present uneven reflectivity decay when compared with healthy vessels. The fitting error has revealed as the most favorable indicator for aneurysm diagnosis as it provides a measure of how uniform is the decay along the vessel thickness.

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Eusebio Real, Alma Eguizabal, Alejandro Pontón, J. Fernando Val-Bernal, Marta Mayorga, José M. Revuelta, José López-Higuera, and Olga M. Conde "Optical coherence tomography assessment of vessel wall degradation in aneurysmatic thoracic aortas", Proc. SPIE 8802, Optical Coherence Tomography and Coherence Techniques VI, 88020G (18 June 2013); https://doi.org/10.1117/12.2032592

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KEYWORDS

Optical coherence tomography

Tissues

Backscatter

Interfaces

Reflectivity

Imaging systems

Natural surfaces

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