Single molecule sensing with carbon nanotube devices

Yongki Choi; Patrick C. Sims; Tivoli J. Olsen; Mariam Iftikhar; Brad L. Corso; O. Tolga Gul; Gregory A. Weiss; Philip G. Collins

doi:10.1117/12.2025661

24 September 2013 Single molecule sensing with carbon nanotube devices

Yongki Choi, Patrick C. Sims, Tivoli J. Olsen, Mariam Iftikhar, Brad L. Corso, O. Tolga Gul, Gregory A. Weiss, Philip G. Collins

Author Affiliations +

Proceedings Volume 8814, Carbon Nanotubes, Graphene, and Associated Devices VI; 88140Q (2013) https://doi.org/10.1117/12.2025661
Event: SPIE NanoScience + Engineering, 2013, San Diego, California, United States

Abstract

Nanoscale electronic devices like field-effect transistors have long promised to provide sensitive, label-free detection of biomolecules. In particular, single-walled carbon nanotubes have the requisite sensitivity to detect single molecule events and sufficient bandwidth to directly monitor single molecule dynamics in real time. Recent measurements have demonstrated this premise by monitoring the dynamic, single-molecule processivity of three different enzymes: lysozyme, protein Kinase A, and the Klenow fragment of DNA polymerase I. In each case, recordings resolved detailed trajectories of tens of thousands of individual chemical events and provided excellent statistics for single-molecule events. This electronic technique has a temporal resolution approaching 1 microsecond, which provides a new window for observing brief, intermediate transition states. In addition, the devices are indefinitely stable, so that the same molecule can be observed for minutes and hours. The extended recordings provide new insights into rare events like transitions to chemically-inactive conformations.

Citation Download Citation

Yongki Choi, Patrick C. Sims, Tivoli J. Olsen, Mariam Iftikhar, Brad L. Corso, O. Tolga Gul, Gregory A. Weiss, and Philip G. Collins "Single molecule sensing with carbon nanotube devices", Proc. SPIE 8814, Carbon Nanotubes, Graphene, and Associated Devices VI, 88140Q (24 September 2013); https://doi.org/10.1117/12.2025661

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