In vivo photoacoustic imaging of breast cancer tumor with HER2-targeted nanodiamonds

Ti Zhang; Huizhong Cui; Chia-Yi Fang; Janggun Jo; Xinmai Yang; Huan-Cheng Chang; M. Laird Forrest

doi:10.1117/12.2027253

20 September 2013 In vivo photoacoustic imaging of breast cancer tumor with HER2-targeted nanodiamonds

Ti Zhang, Huizhong Cui, Chia-Yi Fang, Janggun Jo, Xinmai Yang, Huan-Cheng Chang, M. Laird Forrest

Proceedings Volume 8815, Nanoimaging and Nanospectroscopy; 881504 (2013) https://doi.org/10.1117/12.2027253
Event: SPIE NanoScience + Engineering, 2013, San Diego, California, United States

Abstract

Radiation-damaged nanodiamonds (NDs) are ideal optical contrast agents for photoacoustic (PA) imaging in biological tissues due to their good biocompatibility and high optical absorbance in the near-infrared (NIR) range. Acid treated NDs are oxidized to form carboxyl groups on the surface, functionalized with polyethylene glycol (PEG) and human epidermal growth factor receptor 2 (HER2) targeting ligand for breast cancer tumor imaging. Because of the specific binding of the ligand conjugated NDs to the HER2-overexpressing murine breast cancer cells (4T1.2 neu), the tumor tissues are significantly delineated from the surrounding normal tissue at wavelength of 820 nm under the PA imaging modality. Moreover, HER2 targeted NDs (HER2-PEG-NDs) result in higher accumulation in HER2 positive breast tumors as compared to non-targeted NDs after intravenous injection (i.v.). Longer retention time of HER-PEG-NDs is observed in HER2 overexpressing tumor model than that in negative tumor model (4T1.2). This demonstrates that targeting moiety conjugated NDs have great potential for the sensitive detection of cancer tumors and provide an attractive delivery strategy for anti-cancer drugs.

Citation Download Citation

Ti Zhang, Huizhong Cui, Chia-Yi Fang, Janggun Jo, Xinmai Yang, Huan-Cheng Chang, and M. Laird Forrest "In vivo photoacoustic imaging of breast cancer tumor with HER2-targeted nanodiamonds", Proc. SPIE 8815, Nanoimaging and Nanospectroscopy, 881504 (20 September 2013); https://doi.org/10.1117/12.2027253

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