Simple detection method of amyloid-beta peptide using p-FET with optical filtering layer and magnetic particle

Kwan-Soo Kim; Chang-Beom Kim; Ki-Bong Song

doi:10.1117/12.2017829

20 May 2013 Simple detection method of amyloid-beta peptide using p-FET with optical filtering layer and magnetic particle

Kwan-Soo Kim, Chang-Beom Kim, Ki-Bong Song

Author Affiliations +

Proceedings Volume 8879, Nano-Bio Sensing, Imaging, and Spectroscopy; 887907 (2013) https://doi.org/10.1117/12.2017829
Event: Nano-Bio Sensing, Imaging and Spectroscopy, 2013, Jeju, Korea, Republic of

Abstract

This article describes a novel method for detection of amyloid-β (Aβ) peptide that utilizes a photo-sensitive field-effect transistor (p-FET). According to a recent study, Aβ protein is known to play a central role in the pathogenesis of Alzheimer’s disease (AD). Accordingly, we investigated the variation of photo current of the p-FET generated by the magnetic beads conjugated with Aβ peptides which are placed on the p-FET sensing areas. Additionally, in order to amplify the output signal, we used the lock-in amplifier (LIA) and confirmed the generating the photo current by a small incident light power under 100 μW. It means that it is possible to simply detect a certain protein using magnetic beads conjugated with Aβ peptide and fluorescent label located on the p-FET device. Therefore, in this paper, we suggest that our method could detect tiny amounts of Aβ peptide for early diagnosis of AD using the p-FET devices.

Citation Download Citation

Kwan-Soo Kim, Chang-Beom Kim, and Ki-Bong Song "Simple detection method of amyloid-beta peptide using p-FET with optical filtering layer and magnetic particle", Proc. SPIE 8879, Nano-Bio Sensing, Imaging, and Spectroscopy, 887907 (20 May 2013); https://doi.org/10.1117/12.2017829

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