Detection of biological analytes using nanomechanical infrared spectroscopy with a nanoporous microcantilever

Dongkyu Lee; Seonghwan Kim; Thomas Thundat

doi:10.1117/12.2017771

20 May 2013 Detection of biological analytes using nanomechanical infrared spectroscopy with a nanoporous microcantilever

Dongkyu Lee, Seonghwan Kim, Thomas Thundat

Author Affiliations +

Proceedings Volume 8879, Nano-Bio Sensing, Imaging, and Spectroscopy; 88790Q (2013) https://doi.org/10.1117/12.2017771
Event: Nano-Bio Sensing, Imaging and Spectroscopy, 2013, Jeju, Korea, Republic of

Abstract

The highly sensitive nanoporous cantilever beam without immobilized receptors was combined with highly selective mid-infrared (IR) spectroscopy for molecular recognition of analytes using characteristic molecular vibrations. Unlike conventional IR spectroscopy, in addition, the detection sensitivity and resolution are drastically enhanced by combining high power tunable quantum cascade laser with a nanoporous cantilever having large surface area, low modulus, and nanowell structures. Further, analytes can be easily loaded on the porous microcantilever without receptor due to nanowells. In addition, orthogonal signals, variations in the mass and IR spectrum, provide more reliable and quantitative results including physical as well as chemical information of samples. We have used this technique to rapidly identify single and double stranded DNA.

Citation Download Citation

Dongkyu Lee, Seonghwan Kim, and Thomas Thundat "Detection of biological analytes using nanomechanical infrared spectroscopy with a nanoporous microcantilever", Proc. SPIE 8879, Nano-Bio Sensing, Imaging, and Spectroscopy, 88790Q (20 May 2013); https://doi.org/10.1117/12.2017771

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