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20 May 2013 Mouse neuroblastoma cell based model and the effect of epileptic events on calcium oscillations and neural spikes
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Proceedings Volume 8879, Nano-Bio Sensing, Imaging, and Spectroscopy; 88790T (2013) https://doi.org/10.1117/12.2017666
Event: Nano-Bio Sensing, Imaging and Spectroscopy, 2013, Jeju, Korea, Republic of
Abstract
Recently, Mouse neuroblastoma cells are considered as an attractive model for the study of human neurological and prion diseases, and intensively used as a model system in different areas. Among those areas, differentiation of neuro2a (N2A) cells, receptor mediated ion current, and glutamate induced physiological response are actively investigated. The reason for the interest to mouse neuroblastoma N2A cells is that they have a fast growing rate than other cells in neural origin with a few another advantages. This study evaluated the calcium oscillations and neural spikes recording of mouse neuroblastoma N2A cells in an epileptic condition. Based on our observation of neural spikes in mouse N2A cell with our proposed imaging modality, we report that mouse neuroblastoma N2A cells can be an important model related to epileptic activity studies. It is concluded that the mouse neuroblastoma N2A cells produce the epileptic spikes in vitro in the same way as produced by the neurons or the astrocytes. This evidence advocates the increased and strong level of neurotransmitters release by enhancement in free calcium using the 4-aminopyridine which causes the mouse neuroblastoma N2A cells to produce the epileptic spikes and calcium oscillation.
© (2013) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Suhwan Kim, Juyeong Baek, Unsang Jung, Sangwon Lee, Woonggyu Jung, Jeehyun Kim, and Shinwon Kang "Mouse neuroblastoma cell based model and the effect of epileptic events on calcium oscillations and neural spikes", Proc. SPIE 8879, Nano-Bio Sensing, Imaging, and Spectroscopy, 88790T (20 May 2013); https://doi.org/10.1117/12.2017666
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