Selective biosensing using straight long-range surface plasmon waveguides

O. Krupin; Chen Wang; Pierre Berini

doi:10.1117/12.2036362

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11 October 2013 Selective biosensing using straight long-range surface plasmon waveguides

O. Krupin, Chen Wang, Pierre Berini

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Proceedings Volume 8915, Photonics North 2013; 89151E (2013) https://doi.org/10.1117/12.2036362
Event: Photonics North 2013, 2013, Ottawa, Canada

Abstract

A novel biosensing platform based on long-range surface plasmon waveguides is demonstrated for selective biosensing. The sensor consists of gold waveguides embedded in CYTOP with a microfluidic channel. Gold surfaces were modified by forming a self-assembled monolayer (SAM) and further they were functionalized by proper receptor (antibodies) with carbodiimide chemistry. Investigation of biochemical interactions were performed with human immunoglobulin (Ig). Human immunoglobulin M (IgM) kappa chain (IgM-κ) was tested on the waveguide, functionalized with anti-human immunoglobulin-kappa specific chain (anti-Igκ). As a negative control, human IgM lambda chain (IgM-λ) was tested on anti-Igκ surface. The response for IgM- sample was 0.173 dBm and that for IgM-λ was 0.033. The ratio of the responses ΔS(IgM-κ)/ ΔS(IgM-λ) was found to be 5.3.

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O. Krupin, Chen Wang, and Pierre Berini "Selective biosensing using straight long-range surface plasmon waveguides", Proc. SPIE 8915, Photonics North 2013, 89151E (11 October 2013); https://doi.org/10.1117/12.2036362

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