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11 October 2013Selective biosensing using straight long-range surface plasmon waveguides
A novel biosensing platform based on long-range surface plasmon waveguides is demonstrated for selective biosensing.
The sensor consists of gold waveguides embedded in CYTOP with a microfluidic channel. Gold surfaces were modified
by forming a self-assembled monolayer (SAM) and further they were functionalized by proper receptor (antibodies) with
carbodiimide chemistry. Investigation of biochemical interactions were performed with human immunoglobulin (Ig).
Human immunoglobulin M (IgM) kappa chain (IgM-κ) was tested on the waveguide, functionalized with anti-human
immunoglobulin-kappa specific chain (anti-Igκ). As a negative control, human IgM lambda chain (IgM-λ) was tested on
anti-Igκ surface. The response for IgM- sample was 0.173 dBm and that for IgM-λ was 0.033. The ratio of the
responses ΔS(IgM-κ)/ ΔS(IgM-λ) was found to be 5.3.
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O. Krupin, Chen Wang, Pierre Berini, "Selective biosensing using straight long-range surface plasmon waveguides," Proc. SPIE 8915, Photonics North 2013, 89151E (11 October 2013); https://doi.org/10.1117/12.2036362