Effects of laser-exposed gold nanorods on biochemical pathways of neuronal cells

Chiara Paviolo; John W. Haycock; Paul R. Stoddart; Sally L. McArthur

doi:10.1117/12.2033575

7 December 2013 Effects of laser-exposed gold nanorods on biochemical pathways of neuronal cells

Chiara Paviolo, John W. Haycock, Paul R. Stoddart, Sally L. McArthur

Proceedings Volume 8923, Micro/Nano Materials, Devices, and Systems; 89231A (2013) https://doi.org/10.1117/12.2033575
Event: SPIE Micro+Nano Materials, Devices, and Applications, 2013, Melbourne, Victoria, Australia

Abstract

Gold nanorods with citrate termination, poly(4 - styrenesulfonic acid) coating and silica coating were taken up by NG108 - K15 neuronal cells. This process proved to generate reactive oxygen species (ROS) and activate the nuclear factor κ -B (NF - κB). However, subsequent exposure to laser light at the plasmon resonance wavelength showed no long term cell damage or ROS / NF- κB activation. Interestingly, monitoring of intracellular Ca²⁺ signaling showed evidence of photo - generated transients without alteration of other normal cell functions. These results suggest new opportunities for peripheral nerve regeneration treatments and for infrared neural stimulation.

Citation Download Citation

Chiara Paviolo, John W. Haycock, Paul R. Stoddart, and Sally L. McArthur "Effects of laser-exposed gold nanorods on biochemical pathways of neuronal cells", Proc. SPIE 8923, Micro/Nano Materials, Devices, and Systems, 89231A (7 December 2013); https://doi.org/10.1117/12.2033575

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