Monte Carlo modeling of pigmented lesions

Daniel Gareau; Steven Jacques; James Krueger

doi:10.1117/12.2040473

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4 March 2014 Monte Carlo modeling of pigmented lesions

Daniel Gareau, Steven Jacques, James Krueger

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Proceedings Volume 8926, Photonic Therapeutics and Diagnostics X; 89260V (2014) https://doi.org/10.1117/12.2040473
Event: SPIE BiOS, 2014, San Francisco, California, United States

Abstract

Colors observed in clinical dermoscopy are critical to diagnosis but the mechanisms that lead to the spectral components of diffuse reflectance are more than meets the eye: combinations of the absorption and scattering spectra of the biomolecules as well as the “structural color” effect of skin anatomy. We modeled diffuse remittance from skin based on histopathology. The optical properties of the tissue types were based on the relevant chromophores and scatterers. The resulting spectral images mimic the appearance of pigmented lesions quite well when the morphology is mathematically derived but limited when based on histopathology, raising interesting questions about the interaction between various wavelengths with various pathological anatomical features.

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Daniel Gareau, Steven Jacques, and James Krueger "Monte Carlo modeling of pigmented lesions", Proc. SPIE 8926, Photonic Therapeutics and Diagnostics X, 89260V (4 March 2014); https://doi.org/10.1117/12.2040473

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