Enhanced diagnostic of skin conditions by polarized laser speckles:
phantom studies and computer modeling

Lioudmila Tchvialeva; Tim K. Lee; Igor Markhvida; Haishan Zeng; Alexander Doronin; Igor Meglinski

doi:10.1117/12.2040192

4 March 2014 Enhanced diagnostic of skin conditions by polarized laser speckles: phantom studies and computer modeling

Lioudmila Tchvialeva, Tim K. Lee, Igor Markhvida, Haishan Zeng, Alexander Doronin, Igor Meglinski

Proceedings Volume 8926, Photonic Therapeutics and Diagnostics X; 89260X (2014) https://doi.org/10.1117/12.2040192
Event: SPIE BiOS, 2014, San Francisco, California, United States

Abstract

The incidence of the skin melanoma, the most commonly fatal form of skin cancer, is increasing faster than any other potentially preventable cancer. Clinical practice is currently hampered by the lack of the ability to rapidly screen the functional and morphological properties of tissues. In our previous study we show that the quantification of scattered laser light polarization provides a useful metrics for diagnostics of the malignant melanoma. In this study we exploit whether the image speckle could improve skin cancer diagnostic in comparison with the previously used free-space speckle. The study includes skin phantom measurements and computer modeling. To characterize the depolarization of light we measure the spatial distribution of speckle patterns and analyse their depolarization ratio taken into account radial symmetry. We examine the dependences of depolarization ratio vs. roughness for phantoms which optical properties are of the order of skin lesions. We demonstrate that the variation in bulk optical properties initiates the assessable changes in the depolarization ratio. We show that image speckle differentiates phantoms significantly better than free-space speckle. The results of experimental measurements are compared with the results of Monte Carlo simulation.

Citation Download Citation

Lioudmila Tchvialeva, Tim K. Lee, Igor Markhvida, Haishan Zeng, Alexander Doronin, and Igor Meglinski "Enhanced diagnostic of skin conditions by polarized laser speckles: phantom studies and computer modeling", Proc. SPIE 8926, Photonic Therapeutics and Diagnostics X, 89260X (4 March 2014); https://doi.org/10.1117/12.2040192

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available