Determination of tissue optical properties in PDT treated head and neck patients

Andreea Dimofte; Jarod C. Finlay; Anna V. Sharikova; Keith A. Cengel; Peter Ahn; Theresa M. Busch; Timothy C. Zhu

doi:10.1117/12.2037831

28 March 2014 Determination of tissue optical properties in PDT treated head and neck patients

Andreea Dimofte, Jarod C. Finlay, Anna V. Sharikova, Keith A. Cengel, Peter Ahn, Theresa M. Busch, Timothy C. Zhu

Proceedings Volume 8926, Photonic Therapeutics and Diagnostics X; 89262C (2014) https://doi.org/10.1117/12.2037831
Event: SPIE BiOS, 2014, San Francisco, California, United States

Abstract

Determination of optical properties (absorption (μ_a) and scattering (μ_s’) coefficients) in human tissue is important when it comes to accurate calculation of fluence rate in and around tissue area. ALA application to the tissue induces production of protoporphyrin IX when activated by red light. Changes in the tissue optical properties can send information such as treatment outcome and tissue drug concentration. Patients in this study were treated with PDT for head and neck mucosal dysplasia. They were enrolled in a phase I study of escalating light doses and oral ALA with 60mg/kg. Red light at 630nm was administered to the tumor from a laser. The light dose was escalated from 50-200J/cm² with a measured fluence rate at tissue surface of 100mW/cm². We developed a light detection device for the purpose of determining optical properties in vivo using the semi-infinite method. The light detection device consists of two parallel, placed 5mm apart. In one of the catheters a 2 mm long linear diffusing light source is placed while in the second catheter, a calibrated isotropic detector is placed. The detector is scanned along the length of the light source containing catheter. Scans are done with the device placed on the treatment area (tumor) and on the normal tissue. Optical properties were measured in-vivo before and after PDT delivery for both normal tissue and tumor.

Citation Download Citation

Andreea Dimofte, Jarod C. Finlay, Anna V. Sharikova, Keith A. Cengel, Peter Ahn, Theresa M. Busch, and Timothy C. Zhu "Determination of tissue optical properties in PDT treated head and neck patients", Proc. SPIE 8926, Photonic Therapeutics and Diagnostics X, 89262C (28 March 2014); https://doi.org/10.1117/12.2037831

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