Diagnostic accuracy of integrated intravascular ultrasound and optical coherence tomography (IVUS-OCT) system for coronary plaque characterization

Jiawen Li; Teng Ma; Dilbahar Mohar; Adrian Correa; Hataka Minami; Joseph Jing; Qifa Zhou; Pranav M. Patel; Zhongping Chen

doi:10.1117/12.2037886

4 March 2014 Diagnostic accuracy of integrated intravascular ultrasound and optical coherence tomography (IVUS-OCT) system for coronary plaque characterization

Jiawen Li, Teng Ma, Dilbahar Mohar, Adrian Correa, Hataka Minami, Joseph Jing, Qifa Zhou, Pranav M. Patel, Zhongping Chen

Author Affiliations +

Proceedings Volume 8926, Photonic Therapeutics and Diagnostics X; 892635 (2014) https://doi.org/10.1117/12.2037886
Event: SPIE BiOS, 2014, San Francisco, California, United States

Abstract

Intravascular ultrasound (IVUS) imaging and optical coherence tomography (OCT), two commonly used intracoronary imaging modalities, play important roles in plaque evaluation. The combined use of IVUS (to visualize the entire plaque volume) and OCT (to quantify the thickness of the plaque cap, if any) is hypothesized to increase plaque diagnostic accuracy. Our group has developed a fully-integrated dual-modality IVUS-OCT imaging system and 3.6F catheter for simultaneous IVUS-OCT imaging with a high resolution and deep penetration depth. However, the diagnostic accuracy of an integrated IVUS-OCT system has not been investigated. In this study, we imaged 175 coronary artery sites (241 regions of interest) from 20 cadavers using our previous reported integrated IVUS-OCT system. IVUS-OCT images were read by two skilled interventional cardiologists. Each region of interest was classified as either calcification, lipid pool or fibrosis. Comparing the diagnosis by cardiologists using IVUSOCT images with the diagnosis by the pathologist, we calculated the sensitivity and specificity for characterization of calcification, lipid pool or fibrosis with this integrated system. In vitro imaging of cadaver coronary specimens demonstrated the complementary nature of these two modalities for plaques classification. A higher accuracy was shown than using a single modality alone.

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Jiawen Li, Teng Ma, Dilbahar Mohar, Adrian Correa, Hataka Minami, Joseph Jing, Qifa Zhou, Pranav M. Patel, and Zhongping Chen "Diagnostic accuracy of integrated intravascular ultrasound and optical coherence tomography (IVUS-OCT) system for coronary plaque characterization", Proc. SPIE 8926, Photonic Therapeutics and Diagnostics X, 892635 (4 March 2014); https://doi.org/10.1117/12.2037886

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