Hemodynamic measurements in deep brain tissues of humans by near-infrared time-resolved spectroscopy

Hiroaki Suzuki; Motoki Oda; Etsuko Yamaki; Toshihiko Suzuki; Daisuke Yamashita; Kenji Yoshimoto; Shu Homma; Yutaka Yamashita

doi:10.1117/12.2038689

5 March 2014 Hemodynamic measurements in deep brain tissues of humans by near-infrared time-resolved spectroscopy

Hiroaki Suzuki, Motoki Oda, Etsuko Yamaki, Toshihiko Suzuki, Daisuke Yamashita, Kenji Yoshimoto, Shu Homma, Yutaka Yamashita

Author Affiliations +

Proceedings Volume 8928, Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics; 89280O (2014) https://doi.org/10.1117/12.2038689
Event: SPIE BiOS, 2014, San Francisco, California, United States

Abstract

Using near-infrared time-resolved spectroscopy (TRS), we measured the human head in transmittance mode to obtain the optical properties, tissue oxygenation, and hemodynamics of deep brain tissues in 50 healthy adult volunteers. The right ear canal was irradiated with 3-wavelengths of pulsed light (760, 795, and 835nm), and the photons passing through the human head were collected at the left ear canal. Optical signals with sufficient intensity could be obtained from 46 of the 50 volunteers. By analyzing the temporal profiles based on the photon diffusion theory, we successfully obtained absorption coefficients for each wavelength. The levels of oxygenated hemoglobin (HbO₂), deoxygenated hemoglobin (Hb), total hemoglobin (tHb), and tissue oxygen saturation (SO₂) were then determined by referring to the hemoglobin spectroscopic data. Compared with the SO₂ values for the forehead measurements in reflectance mode, the SO₂ values of the transmittance measurements of the human head were approximately 10% lower, and tHb values of the transmittance measurements were always lower than those of the forehead reflectance measurements. Moreover, the level of hemoglobin and the SO₂ were strongly correlated between the human head measurements in transmittance mode and the forehead measurements in the reflectance mode, respectively. These results demonstrated a potential application of this TRS system in examining deep brain tissues of humans.

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Hiroaki Suzuki, Motoki Oda, Etsuko Yamaki, Toshihiko Suzuki, Daisuke Yamashita, Kenji Yoshimoto, Shu Homma, and Yutaka Yamashita "Hemodynamic measurements in deep brain tissues of humans by near-infrared time-resolved spectroscopy", Proc. SPIE 8928, Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics, 89280O (5 March 2014); https://doi.org/10.1117/12.2038689

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