Air-puff OCE for assessment of mouse cornea in vivo

Jiasong Li; Shang Wang; Manmohan Singh; Salavat Aglyamov; Stanislav Emelianov; Michael Twa; Kirill V. Larin

doi:10.1117/12.2042258

28 February 2014 Air-puff OCE for assessment of mouse cornea in vivo

Jiasong Li, Shang Wang, Manmohan Singh, Salavat Aglyamov, Stanislav Emelianov, Michael Twa, Kirill V. Larin

Proceedings Volume 8930, Ophthalmic Technologies XXIV; 893004 (2014) https://doi.org/10.1117/12.2042258
Event: SPIE BiOS, 2014, San Francisco, California, United States

Abstract

We characterize the relaxation rates of deformations created by focused air puffs with the use of phasestabilized swept source optical coherence elastography (PhS-SSOCE) in tissue-mimicking gelatin phantoms of various concentrations and mouse corneas of different ages in vivo. The results indicate that gelatin of varying concentrations and corneas from different aged mice have different relaxation rates. In addition, the results show that phantoms with higher concentration gelatin and corneas of older mice have higher relaxation rates, which can be attributed to stiffer material. Because this method is non-contact, noninvasive, and utilizes a minimal force which induces a deformation on the scale of μm, this method can be used to study the biomechanical properties of sensitive tissues, such as the cornea.

Citation Download Citation

Jiasong Li, Shang Wang, Manmohan Singh, Salavat Aglyamov, Stanislav Emelianov, Michael Twa, and Kirill V. Larin "Air-puff OCE for assessment of mouse cornea in vivo", Proc. SPIE 8930, Ophthalmic Technologies XXIV, 893004 (28 February 2014); https://doi.org/10.1117/12.2042258

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available