UV transmittance during the crosslinking procedure: tunable treatment

Victor A. C. Lincoln; Marcio M. Mello; Liliane Ventura

doi:10.1117/12.2036641

28 February 2014 UV transmittance during the crosslinking procedure: tunable treatment

Victor A. C. Lincoln, Marcio M. Mello, Liliane Ventura

Proceedings Volume 8930, Ophthalmic Technologies XXIV; 89301F (2014) https://doi.org/10.1117/12.2036641
Event: SPIE BiOS, 2014, San Francisco, California, United States

Abstract

The transmittance of UVA light through the in vitro human cornea over the thickness of 400um during the corneal collagen cross-linking procedure has been measured using an optical fiber (600 μm core diameter) fixed just before the cornea and attached to Spectrophotometer. The 10 corneas, (average of 6 days post-mortem) were washed with saline and cross-linked with the currently used protocol. To enhance absorption of UV radiation, Riboflavin solution (0.1% and 400 mOsm) was applied prior to and during exposure. The UVA beam - 365nm ± 5nm at 3mW/cm2 ± 0.003mW/cm² - was focused directly onto the corneal stroma. The measured average transmittance of the cornea without Riboflavin was 64.1%. Preceding the irradiation but after 6 applications of Riboflavin at 5min intervals (total of 30min) transmittance decreased to 21.1%. The 30min of irradiation were then accompanied by an additional 6 applications of Riboflavin at 5min intervals (for a total of treatment time of 1h), resulting in a further decrease in transmittance to 12.2%, which is in agreement with current literature. The average transmittance in terms of energy during the 30 minutes irradiation procedure fluctuated from 0.63 to 0.37 mW/cm². These results indicate different levels of UV transmittance during treatment, leading to consider a new personalized treatment with tunable UV power irradiation.

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Victor A. C. Lincoln, Marcio M. Mello, and Liliane Ventura "UV transmittance during the crosslinking procedure: tunable treatment", Proc. SPIE 8930, Ophthalmic Technologies XXIV, 89301F (28 February 2014); https://doi.org/10.1117/12.2036641

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KEYWORDS

Cornea

Transmittance

Ultraviolet radiation

Absorption

Collagen

Eye

Safety

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