Mueller polarimetry for the detection of cancers

E. Du; Honghui He; Nan Zeng; Yihong Guo; Minghao Sun; Hui Ma; Shaoxiong Liu; Minghua Li

doi:10.1117/12.2038853

27 February 2014 Mueller polarimetry for the detection of cancers

E. Du, Honghui He, Nan Zeng, Yihong Guo, Minghao Sun, Hui Ma, Shaoxiong Liu, Minghua Li

Proceedings Volume 8935, Advanced Biomedical and Clinical Diagnostic Systems XII; 89350S (2014) https://doi.org/10.1117/12.2038853
Event: SPIE BiOS, 2014, San Francisco, California, United States

Abstract

Polarization measurements allow one to enhance imaging contrast of superficial tissues and obtain new polarization sensitive parameters for better description of the micro- and macro- structural and optical properties of complex tissues. Since the majority of cancers originate in the epithelial layer, probing the morphological and pathological changes in the superficial tissues using an expended parameter set and with improved spatial resolution and contrasts will lead to new clues on the early clinical detection of cancers. In this wok, we carry out polarization imaging on cancerous tissues and look for cancer specific features. Using a scattering model, which approximates the anisotropic biological tissues to a mixture of spherical and cylindrical scatterers imbedded in birefringent ambient media, and a Monte Carlo simulation program, we examine the relationship between the micro-structure of the model and the characteristic polarization features. The studies help to understand the contrast mechanism of polarization sensitive measurements for different cancers and provide the basis for potential clinical applications.

Citation Download Citation

E. Du, Honghui He, Nan Zeng, Yihong Guo, Minghao Sun, Hui Ma, Shaoxiong Liu, and Minghua Li "Mueller polarimetry for the detection of cancers", Proc. SPIE 8935, Advanced Biomedical and Clinical Diagnostic Systems XII, 89350S (27 February 2014); https://doi.org/10.1117/12.2038853

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