Analysis of thermal effects in endoscopic nanocarriers-based photodynamic therapy applied to esophageal diseases

I. Salas-García; F. Fanjul-Vélez; N. Ortega-Quijano; O. Wilfert; L. Hudcova; J. Poliak; P. Barcik; J. L. Arce-Diego

doi:10.1117/12.2039209

26 February 2014 Analysis of thermal effects in endoscopic nanocarriers-based photodynamic therapy applied to esophageal diseases

I. Salas-García, F. Fanjul-Vélez, N. Ortega-Quijano, O. Wilfert, L. Hudcova, J. Poliak, P. Barcik, J. L. Arce-Diego

Author Affiliations +

Proceedings Volume 8941, Optical Interactions with Tissue and Cells XXV; and Terahertz for Biomedical Applications; 89410C (2014) https://doi.org/10.1117/12.2039209
Event: SPIE BiOS, 2014, San Francisco, California, United States

Abstract

In this work we propose a predictive model that allows the study of thermal effects produced when the optical radiation interacts with an esophageal or stomach disease with gold nanoparticles embedded. The model takes into account light distribution in the tumor tissue by means of a Monte Carlo method. Mie theory is used to obtain the gold nanoparticles optical properties and the thermal model employed is based on the bio-heat equation. The complete model was applied to two types of tumoral tissue (squamous cell carcinoma located in the esophagus and adenocarcinoma in the stomach) in order to study the thermal effects induced by the inclusion of gold nanoparticles.

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I. Salas-García, F. Fanjul-Vélez, N. Ortega-Quijano, O. Wilfert, L. Hudcova, J. Poliak, P. Barcik, and J. L. Arce-Diego "Analysis of thermal effects in endoscopic nanocarriers-based photodynamic therapy applied to esophageal diseases", Proc. SPIE 8941, Optical Interactions with Tissue and Cells XXV; and Terahertz for Biomedical Applications, 89410C (26 February 2014); https://doi.org/10.1117/12.2039209

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KEYWORDS

Nanoparticles

Tissue optics

Gold

Tumor growth modeling

Tissues

Photodynamic therapy

Absorption

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