High-speed time-reversed ultrasonically encoded (TRUE) optical focusing inside dynamic scattering media at 793 nm

Yan Liu; Puxiang Lai; Cheng Ma; Xiao Xu; Yuta Suzuki; Alexander A. Grabar; Lihong V. Wang

doi:10.1117/12.2039815

3 March 2014 High-speed time-reversed ultrasonically encoded (TRUE) optical focusing inside dynamic scattering media at 793 nm

Yan Liu, Puxiang Lai, Cheng Ma, Xiao Xu, Yuta Suzuki, Alexander A. Grabar, Lihong V. Wang

Author Affiliations +

Proceedings Volume 8943, Photons Plus Ultrasound: Imaging and Sensing 2014; 894339 (2014) https://doi.org/10.1117/12.2039815
Event: SPIE BiOS, 2014, San Francisco, California, United States

Abstract

Time-reversed ultrasonically encoded (TRUE) optical focusing is an emerging technique that focuses light deep into scattering media by phase-conjugating ultrasonically encoded diffuse light. In previous work, the speed of TRUE focusing was limited to no faster than 1 Hz by the response time of the photorefractive phase conjugate mirror, or the data acquisition and streaming speed of the digital camera; photorefractive-crystal-based TRUE focusing was also limited to the visible spectral range. These time-consuming schemes prevent this technique from being applied in vivo, since living biological tissue has a speckle decorrelation time on the order of a millisecond. In this work, using a Tedoped Sn₂P₂S₆ photorefractive crystal at a near-infrared wavelength of 793 nm, we achieved TRUE focusing inside dynamic scattering media having a speckle decorrelation time as short as 7.7 ms. As the achieved speed approaches the tissue decorrelation rate, this work is an important step forward toward in vivo applications of TRUE focusing in deep tissue imaging, photodynamic therapy, and optical manipulation.

Citation Download Citation

Yan Liu, Puxiang Lai, Cheng Ma, Xiao Xu, Yuta Suzuki, Alexander A. Grabar, and Lihong V. Wang "High-speed time-reversed ultrasonically encoded (TRUE) optical focusing inside dynamic scattering media at 793 nm", Proc. SPIE 8943, Photons Plus Ultrasound: Imaging and Sensing 2014, 894339 (3 March 2014); https://doi.org/10.1117/12.2039815

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