Mechanistic studies of systemic immune responses induced by laser-nanotechnology

Wei R. Chen; Feifan Zhou; Brock Henderson; Bailey Vasquez; Hong Liu; Tomas Hode; Robert E. Nordquist

doi:10.1117/12.2041265

27 February 2014 Mechanistic studies of systemic immune responses induced by laser-nanotechnology

Wei R. Chen, Feifan Zhou, Brock Henderson, Bailey Vasquez, Hong Liu, Tomas Hode, Robert E. Nordquist

Proceedings Volume 8944, Biophotonics and Immune Responses IX; 89440U (2014) https://doi.org/10.1117/12.2041265
Event: SPIE BiOS, 2014, San Francisco, California, United States

Abstract

With the help of the specific absorption spectrum of carbon nanotubes, we achieved selective photothermal tumor cell destruction, particularly using a near-infrared laser to reduce potential damage to untargeted tissues. Combined with immunological stimulation, using a novel adjuvant, we also observed the anti-tumor immune responses when treating animal tumors using the laser-nano treatment. In fact, the local application of laser-nano-immunotherapy appeared to result in a systemic curative effect. In our mechanistic study, we found that the laser-nano-immuno treatment can activate antigen-presenting cells, such as dendritic cells (DCs). More importantly, the uptake and presentation of antigens by these antigen presenting cells were significantly enhanced, as shown by the strong binding of tumor cells and DCs as well as the proliferation of T cells caused by the DCs after the DCs had been incubated with laser-nano-immuno treated tumors. These cellular observations provide evidence that a systemic anti-tumor immune response was induced by the combination of laser and nanotechnology.

Citation Download Citation

Wei R. Chen, Feifan Zhou, Brock Henderson, Bailey Vasquez, Hong Liu, Tomas Hode, and Robert E. Nordquist "Mechanistic studies of systemic immune responses induced by laser-nanotechnology", Proc. SPIE 8944, Biophotonics and Immune Responses IX, 89440U (27 February 2014); https://doi.org/10.1117/12.2041265

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